Both sides will be pumped for this one, eager to prove themselves heading in to thew finals series.
When the two sides met earlier this year, the Tricolours handed the team from out west their first defeat of the 2013 season.
Since then, the Panthers have continued their good form, losing just four more games up until now.
One of those defeats did come last weekend, in a shock 30-8 loss to the Sharks.
The Tricolours on the other hand, rebounded from their own loss to the Sharks to put away an eager Knights side, 44-18.
Despite struggling at the start of the second half, the Tricolours showed great resilience to turn it all around and run away with the victory.
Head Coach Paul Green has stuck with his starting side who defeated the Knights on Sunday arvo, making just two changes to the bench with the inclusion of Louis Meehan and Brandon Tago.
Meehan was originally named for last weekend's clash but replaced prior to kick off, while Tago will return after a stint on the sideline with a knee injury.
Meehan and Tago replace Su'a Poe and Leilua in the seventeen.